Not known Factual Statements About phenobarbital sodium drug class
Not known Factual Statements About phenobarbital sodium drug class
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pentobarbital will reduce the level or effect of etravirine by affecting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Keep track of.
Observe Carefully (one)pentobarbital will decrease the extent or effect of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Lack of, or diminished reaction to tofacitinib may occur when coadministered with powerful CYP3A4 inducers
pentobarbital decreases amounts of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with strong CYP3A4 inducers; these drugs decrease exposure to vandetanib by nearly forty%.
Contraindicated (one)pentobarbital will minimize the extent or effect of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
DOSAGE AND ADMINISTRATION Dosages of barbiturates have to be individualized with whole familiarity with their distinct features and advisable rate of administration.
pentobarbital will lower the extent or effect of tadalafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Keep away from mixture in pulmonary HTN sufferers. For individuals with ED, observe response to tadalafil very carefully as a result of potential for lessened effectiveness.
Details to the patient: Practitioners must give the following details and instructions to patients receiving barbiturates. The usage of barbiturates carries with it an associated chance of psychological and/or physical dependence. The individual must be warned in opposition to rising the dose of the drug without consulting a physician.
pentobarbital will lower the level or effect of estradiol vaginal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will lower the extent or effect of disopyramide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Not known.
pentobarbital will lower the level or effect of tamoxifen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will minimize the level or more info effect of etonogestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital increases effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Keep track of. Coadministration of ifosfamide with CYP2B6 inducers might increase metabolism of ifosfamide to its metabolite. Observe for greater effects/toxicities if mixed with CYP2B6 inducers.
pentobarbital will minimize the level or effect of atazanavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.
Anticoagulants: Phenobarbital lowers the plasma amounts of dicumarol (name Formerly used: bishydroxycoumarin) and causes a decrease in anticoagulant action as calculated with the prothrombin time. Barbiturates can induce hepatic microsomal enzymes resulting in amplified metabolism and lowered anticoagulant reaction of oral anticoagulants (e.